Fox is keeping things simple this fall — and that includes the return of its hit medical drama Doc, which is set to premiere its 22-episode second season on Tuesday, September 23 at 9/8c.
Adapted from the Italian series Doc – Nelle tue mani, the show stars Molly Parker as Dr. Amy Larsen, a once-brilliant physician who must start her career over after a traumatic brain injury erases the last eight years of her memory. Season 2 will pick up where the first left off — with Amy navigating her personal and professional reset, and new power dynamics at Westside Hospital.
Patrick Walker (Dr. TJ Coleman) and Charlotte Fountain-Jardim (Katie Hamda) have been upped to series regulars this season, joining returning cast members Amirah Vann, Omar Metwally, Jon Ecker, and Anya Banerjee. As previously announced, Felicity Huffman joins the cast in Season 2 as Dr. Joan Ridley, Amy’s former mentor and the hospital’s new Chief of Internal Medicine.
The show was renewed earlier this year following strong viewership. It not only became Fox’s most-watched multiplatform debut in over five years with 16 million views across platforms, but also saw a 56% jump in the 18-49 demo from premiere to finale.
Fox’s Full Fall 2025 Premiere Lineup
Fox’s fall strategy is clean and classic: everything premieres in its regular time slot, with no post-NFL stunts or two-hour specials (aside from its usual Sunday comedy block). Scripted programming remains limited — just 4 out of 15 primetime hours — while unscripted competition and game shows dominate.
Here’s what the full Fox fall slate looks like:
Friday, August 29
- 8:00 PM: Fox College Football Friday
Saturday (Ongoing)
- 7:00 PM: Fox Sports Saturday
Monday, September 15
- 8:00 PM: Celebrity Name That Tune
- 9:00 PM: Celebrity Weakest Link (New Series)
Tuesday, September 23
- 8:00 PM: Murder in a Small Town (New Series)
- 9:00 PM: Doc (Season 2 Premiere)
Wednesday, September 24
- 8:00 PM: The Floor
- 9:00 PM: 99 to Beat (New Series)
Thursday, September 25
- 8:00 PM: Hell’s Kitchen
- 9:00 PM: Special Forces: World’s Toughest Test
Sunday, September 28 (Post-NFL Block)
- 8:00 PM: The Simpsons
- 8:30 PM: Universal Basic Guys (New Series)
- 9:00 PM: Krapopolis
- 9:30 PM: Bob’s Burgers
Meanwhile, Family Guy and American Dad! will sit out the fall and return in 2026, alongside The Masked Singer, new dramas Best Medicine and Memory of a Killer, and a reboot of Fear Factor.